FABP5 — Fatty acid binding protein 5
FABP5 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FABP5's module in each cell type
About the gene
| Synonyms | E-FABP, KFABP, PA-FABP |
|---|---|
| Chromosome | 8: 81280536-81284777 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters |
| Biological process | Lipid transport, Transport |
Function
Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors. Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.