CISD3 — CDGSH iron sulfur domain 3
CISD3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CISD3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial Translation Mitochondrial & OxPhos | ARF5, CBX6, CCDC124, DCTN2, DDA1, EIF4E2, FKBP3, GID8 +17 more | View in SCUBA |
| Goblet cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARL6IP4, ATP5F1D, CHCHD10, CYBA, GADD45GIP1, METTL26, MIF, MRPL12 +3 more | View in SCUBA |
| Macrophages | RNA Processing Housekeeping Housekeeping | CNIH4, DDX52, DPH3, EXOSC6, FABP5, GTF2E2, IKBKE, LYSET +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Immunoproteasome Activity Inflammation | ABRACL, ARPC5, BANF1, CARD16, CYBC1, GIMAP2, IMP3, PLAAT4 +4 more |
About the gene
| Synonyms | Miner2, MiNT |
|---|---|
| Chromosome | 17: 38730341-38735605 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.