RNA Processing Housekeeping
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 29 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 29 genes have a known function matching the annotation |
Why this annotation
The module is dominated by RNA processing and biogenesis genes: RBM8A (exon junction complex), RBM15B (RNA binding/m6A), DDX52 (RNA helicase, ribosome biogenesis), EXOSC6 (RNA exosome complex), SRSF10 (splicing factor), MPHOSPH6 (RNA processing), MRPS21 (mitochondrial ribosomal protein), TAF9 (TFIID transcription complex), PSMB3 (proteasome beta subunit), ZNHIT3 (snoRNA biogenesis). These are canonical housekeeping/RNA metabolism genes. PCK2 and IKBKE are peripheral members. The module reflects constitutive RNA processing and protein homeostasis programs active in proliferating/active monocyte-macrophages.
Genes
CISD3, CNIH4, DDX52, DPH3, EXOSC6, FABP5, GTF2E2, IKBKE, LYSET, MCRIP1, MPHOSPH6, MRPS21, NAA60, NBDY, NOC2L, ORAI1, PCK2, PNRC2, PPP6R1, PSMB3, RBM15B, RBM8A, S1PR2, SMCR8, SMIM10L1, SRSF10, TAF9, VAC14, ZNHIT3
Most correlated modules
- Phagocytic Endolysosomal · correlation 0.92
- Mitochondrial Housekeeping · correlation 0.90
- Hypoxia-driven Activation · correlation 0.89
- Osmotic Stress Response · correlation 0.86
- Monocyte Innate Signaling · correlation 0.85
- Glycolytic Redox Metabolism · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.