HAAO — 3-hydroxyanthranilate 3,4-dioxygenase
HAAO belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HAAO's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | COL13A1+ Deep Fibroblast ECM production | APOC1, BMPER, COL13A1, CSF1, GPR63, GPX3, GRIA3, KLRF1 +6 more | View in SCUBA |
About the gene
| Chromosome | 2: 42767089-42792593 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Dioxygenase, Oxidoreductase |
| Biological process | Pyridine nucleotide biosynthesis |
Function
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.