COL13A1+ Deep Fibroblast
Gene co-expression module in Fibroblasts
| Category | ECM production |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include COL13A1 (transmembrane collagen marking a specific fibroblast subset), STMN2 (stathmin-2, neural/stromal marker), GRIA3 (glutamate receptor, neural-like stromal), GPX3 (antioxidant secreted by stromal cells), APOC1 (lipid metabolism), VNN2 (pantetheinase, immune/stromal), BMPER (BMP pathway modulator), CSF1 (macrophage CSF, fibroblast-immune crosstalk), and SEMA3E (semaphorin, axon guidance/stromal). Strongly downregulated in both UC and CD inflammation. COL13A1 and STMN2 together mark a deep lamina propria fibroblast subpopulation with neural-like and ECM features. The broad inflammation response in both UC and CD distinguishes this from M50/M62.
Genes
APOC1, BMPER, COL13A1, CSF1, GPR63, GPX3, GRIA3, HAAO, KLRF1, PPP1R14A, PTGER4, SEMA3E, STMN2, STOX2, VNN2
Most correlated modules
- CYGB+ Quiescent Fibroblast · correlation 0.83
- Homeostatic Fibroblast State · correlation 0.70
- BMP-Wnt Fibroblast Program · correlation 0.64
- Subepithelial Fibroblast · correlation 0.56
- Quiescent Anti-inflammatory Fibroblast · correlation 0.37
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.