KLRF1 — Killer cell lectin like receptor F1
KLRF1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KLRF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | COL13A1+ Deep Fibroblast ECM production | APOC1, BMPER, COL13A1, CSF1, GPR63, GPX3, GRIA3, HAAO +6 more | View in SCUBA |
| Natural Killer cells | Mature NK Identity Cytotoxicity | GMFG, IFITM2, KLF2, KLRD1, LYST, SAMD3, TSPO, XBP1 | View in SCUBA |
About the gene
| Synonyms | CLEC5C, NKp80 |
|---|---|
| Chromosome | 12: 9827481-9845007 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Immunity, Innate immunity |
Function
Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.