CSF1 — Colony stimulating factor 1
CSF1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CSF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Cytotoxic Gut Effector cytotoxicity | ATP8B4, CCND2, CD63, CEBPB, CTSA, GNLY, GNPTAB, GZMA +3 more | View in SCUBA |
| Fibroblasts | COL13A1+ Deep Fibroblast ECM production | APOC1, BMPER, COL13A1, GPR63, GPX3, GRIA3, HAAO, KLRF1 +6 more | View in SCUBA |
| Gamma-delta T cells | Cholesterol Biosynthesis Housekeeping | CRIM1, HS3ST3B1, LDLR, MSMO1, MUC12, NDFIP2, REG1A, SQLE +1 more | |
| Glial cells | Inflammatory Cytokine Signaling Inflammation | BACH1, BTG3, FSTL3, NNMT, PAPPA, PDPN, RAB13, STK17A +3 more | View in SCUBA |
| Macrophages | SPP1 Tissue Remodeling ECM remodeling | BST1, CD52, CHI3L1, CHIT1, FBP1, FGR, FN1, GCHFR +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | Heat Shock Response Stress | AHSA1, BAG3, CACYBP, CAPG, CHORDC1, DNAJA4, DNAJB4, GPR174 +13 more |
About the gene
| Synonyms | M-CSF, MCSF, MGC31930 |
|---|---|
| Chromosome | 1: 109910242-109930992 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins |
| Molecular function | Cytokine, Growth factor |
| Biological process | Immunity, Inflammatory response, Innate immunity |
Function
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.