GPX3 — Glutathione peroxidase 3
GPX3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GPX3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | COL13A1+ Deep Fibroblast ECM production | APOC1, BMPER, COL13A1, CSF1, GPR63, GRIA3, HAAO, KLRF1 +6 more | View in SCUBA |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
| Pericytes | Pericyte Identity Developmental | ADIRF, CLMN, FRMD3, HIGD1B, KLHL23, MAP3K20, PLCE1, TINAGL1 | View in SCUBA |
| Smooth muscle cells | Vascular SMC Identity Contractility | ADIRF, ARPC1A, BCAM, CCDC3, CRIP1, EFHD1, GPRC5C, HRC +10 more | View in SCUBA |
About the gene
| Chromosome | 5: 151020591-151028988 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Oxidoreductase, Peroxidase |
Function
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.