HDAC4 — Histone deacetylase 4
HDAC4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HDAC4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | Cytoskeletal Remodeling Cytoskeletal | ARB2A, ASAP1, ATXN1, GTDC1, MTMR3, NFAT5, ST6GALNAC3, SVIL +2 more |
About the gene
| Synonyms | BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, KIAA0288 |
|---|---|
| Chromosome | 2: 239048168-239401654 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Hydrolase, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.