Cytoskeletal Remodeling
Gene co-expression module in Neutrophils
| Category | Cytoskeletal |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes SVIL (supervillin, actin-membrane linker), ASAP1 (Arf1 GAP involved in cytoskeletal remodeling and migration), and VAV3 (Rho/Rac GEF activating actin polymerization) collectively point to cytoskeletal regulation and cell migration. NFAT5 and HDAC4 add regulatory/epigenetic context. MTMR3 regulates phosphoinositide signaling linked to actin dynamics. ST6GALNAC3 modifies cell surface sialylation relevant to neutrophil adhesion. Overall this module reflects actin cytoskeletal organization programs in neutrophils.
Genes
ARB2A, ASAP1, ATXN1, GTDC1, HDAC4, MTMR3, NFAT5, ST6GALNAC3, SVIL, VAV3, ZFAND3
Most correlated modules
- Actin Cytoskeletal Remodeling · correlation 0.99
- ELMO-DOCK Chemotaxis · correlation 0.97
- Endosomal Vesicle Trafficking · correlation 0.96
- Ubiquitin Regulatory Signaling · correlation 0.96
- Stress Kinase Signaling · correlation 0.94
- JAK-MAPK Signaling · correlation 0.93
- Signal Attenuation · correlation 0.92
- Ubiquitin-Proteasome Turnover · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.