GTDC1 — Glycosyltransferase like domain containing 1
GTDC1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GTDC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Integrin Rap1 Signaling migration & adhesion | ARL3, ATP2B4, ATXN1, DR1, GDE1, GNA15, GRAMD1B, ITGA4 +8 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial RNA Processing Mitochondrial & OxPhos | ABR, DARS1, DENND1C, MRPS30, PDCD4, PMPCB, POLG, PRKD2 +11 more | |
| Macrophages | Golgi Vesicle Trafficking Vesicular traficking | ARMH3, ATG7, CCDC91, CDK17, CLASP1, COG5, COMMD10, COP1 +24 more | View in SCUBA |
| Neutrophils | Cytoskeletal Remodeling Cytoskeletal | ARB2A, ASAP1, ATXN1, HDAC4, MTMR3, NFAT5, ST6GALNAC3, SVIL +2 more |
About the gene
| Synonyms | FLJ11753, Hmat-Xa |
|---|---|
| Chromosome | 2: 143938068-144332568 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Glycosyltransferase that specifically catalyzes mannosylation of cytoplasmic tRNA(Asp) modified with queuosine at position 34 (queuosine(34)). Mannosylates the cyclopentene moiety of queuosine(34) in tRNA(Asp) to form mannosyl-queuosine(34). Mannosylation of queuosine(34) in tRNA(Asp) is required to slow-down elongation at cognate codons, GAC and GAU, thereby regulating protein translation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.