ASAP1 — ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASAP1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ASAP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NFAT activation TCR/AP1/NFKb pathway | AHI1, BCAT1, BICDL1, CPM, CYP7B1, ETV6, FAM107B, FKBP5 +13 more | View in SCUBA |
| Lymphatic endothelial | Rho/Ras GTPase Regulation Cytoskeletal | CADPS2, CDK17, ERC1, ETV6, KIF13A, LDLRAD4, LMBR1, PLEKHG1 +4 more | View in SCUBA |
| Macrophages | Endosomal Vesicle Trafficking Vesicular traficking | ADAM17, AP3B1, ARFGEF1, ARID1B, ARK2N, ATF6, ATP11A, CDC73 +48 more | View in SCUBA |
| Neutrophils | Cytoskeletal Remodeling Cytoskeletal | ARB2A, ATXN1, GTDC1, HDAC4, MTMR3, NFAT5, ST6GALNAC3, SVIL +2 more | |
| Pericytes | TGF-β Cytoskeletal Remodeling Cytoskeletal | ARHGEF12, GRK5, LRRC32, MYH9, RAPGEF2, RFTN1, SERPINH1, TCEAL9 +2 more | View in SCUBA |
About the gene
| Synonyms | CENTB4, DDEF1, KIAA1249, PAP, ZG14P |
|---|---|
| Chromosome | 8: 130052104-130443674 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
| Biological process | Cilium biogenesis/degradation |
Function
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.