ATXN1 — Ataxin 1

ATXN1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ATXN1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Integrin Rap1 Signaling migration & adhesion	ARL3, ATP2B4, DR1, GDE1, GNA15, GRAMD1B, GTDC1, ITGA4 +8 more	View in SCUBA
CD8⁺ T cells	CD8 Effector Maturation T cell maturation	AKAP13, CD81, DDX17, DDX3X, ETS1, IKZF3, JUND, MXD4 +8 more	View in SCUBA
Enterocytes	Colonocyte differentiation TFs Chromatin regulation & transcription	AGAP1, DENND1B, DOCK5, GOLIM4, GRAMD2B, HNF4G, JMJD1C, LCORL +7 more	View in SCUBA
Macrophages	Rho GTPase Signaling Cytoskeletal	ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more	View in SCUBA
Mucosal-associated invariant T cell	SWI/SNF Chromatin Remodeling DNA/chromatin regulation	ABTB3, AOAH, ARID1B, ARID2, ATP8A1, BRAF, CCSER2, CDC42SE2 +13 more
Neutrophils	Cytoskeletal Remodeling Cytoskeletal	ARB2A, ASAP1, GTDC1, HDAC4, MTMR3, NFAT5, ST6GALNAC3, SVIL +2 more

About the gene

Synonyms	ATX1, D6S504E, SCA1
Chromosome	6: 16299112-16761491
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted intracellular proteins
Molecular function	DNA-binding, Repressor, RNA-binding
Biological process	Transcription, Transcription regulation

Function

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ- mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.