NFAT5 — Nuclear factor of activated T cells 5

NFAT5 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NFAT5's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Chromatin modifiers DNA/chromatin regulation	ATP2A3, BIRC6, KDM5A, KMT2C, LPIN1, MBNL1, NCOA3, RBM5 +1 more	View in SCUBA
CD4⁺ T cells	NF-kB regulation TCR/AP1/NFKb pathway	ARIH2, CD58, CYLD, DAD1, DERL1, EED, ELOVL5, OTULIN +9 more	View in SCUBA
Endothelial	NF-κB Stress Signaling Inflammation	AKR1C3, ELK4, EPS15, METRNL, MYCBP2, PALM, PELI2, PGM5 +4 more	View in SCUBA
Gamma-delta T cells	Osmotic Stress Response Stress	BAZ1A, BMPR2, HIPK3, HTT, LIX1L, MAPRE2, RALGAPB, RTN4 +6 more
Goblet cells	Goblet Cell Identity Epithelial development	CELF2, FOXP1, FRYL, GPRIN3, HOXB13, ITPR2, KCTD12, NEDD4L +5 more	View in SCUBA
Lymphatic endothelial	ZEB1-driven EMT endothelial development	ASH1L, CUX1, ERBIN, ITSN2, KIF1B, MKLN1, NIPBL, PAFAH1B1 +7 more	View in SCUBA
Macrophages	Rho GTPase Signaling Cytoskeletal	ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more	View in SCUBA
Mucosal-associated invariant T cell	Splicing Regulation RNA processing & translation	AREG, ARHGAP9, AZIN1, CCNH, CLK1, DDX24, DNAJB6, IL23R +9 more
Neutrophils	Cytoskeletal Remodeling Cytoskeletal	ARB2A, ASAP1, ATXN1, GTDC1, HDAC4, MTMR3, ST6GALNAC3, SVIL +2 more

About the gene

Synonyms	KIAA0827, NF-AT5, NFATL1, NFATZ, OREBP, TONEBP
Chromosome	16: 69565094-69704666
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding
Biological process	DNA damage, Transcription, Transcription regulation

Function

Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'- [ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single- stranded DNA.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.