HEYL — Hes related family bHLH transcription factor with YRPW motif like
HEYL belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HEYL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Smooth muscle cells | Pericyte Notch Identity Development | CD59, EIF1, GPNMB, IFITM2, IGFBP7, INAFM1, ITM2B, PDGFRB +2 more | View in SCUBA |
About the gene
| Synonyms | bHLHb33, HESR3, HEY3 |
|---|---|
| Chromosome | 1: 39623435-39639643 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, DNA-binding, Repressor |
| Biological process | Notch signaling pathway, Transcription, Transcription regulation |
Function
Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.