Pericyte Notch Identity
Gene co-expression module in Smooth muscle cells
| Category | Development |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
PDGFRB, HEYL (Notch3 target restricted to mural cells), IGFBP7, RERG and GPNMB together define a pericyte/immature mural cell state; CD59, IFITM2 and ITM2B are surface/interferon-associated genes commonly co-expressed in perivascular cells, while EIF1/TMEM256 are low-specificity housekeeping passengers explaining the only 'moderate' coherence. Neighborhood context (M11 pericyte basement membrane, M72 vascular matrix) strongly supports a mural/pericyte identity program rather than an inflammatory one.
Genes
CD59, EIF1, GPNMB, HEYL, IFITM2, IGFBP7, INAFM1, ITM2B, PDGFRB, RERG, TMEM256
Most correlated modules
- Contractile SMC Identity · correlation 0.82
- Glucocorticoid Metallothionein Response · correlation 0.78
- Endolysosomal Trafficking · correlation 0.77
- Vascular Matrix Secretion · correlation 0.75
- Calcium Handling · correlation 0.70
- BMP-ID3 Matricellular · correlation 0.69
- MHC-I antigen presentation · correlation 0.68
- Pericyte Basement Membrane · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.