IGFBP7 — Insulin like growth factor binding protein 7

IGFBP7 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IGFBP7's module in each cell type

Cell type	Module	Shares the module with
Endothelial	Endothelial Quiescence Identity Endothelial cell development	CCDC69, CLIC2, CLSTN3, CPD, EPB41L4A, FOXF1, FZD4, KCNE4 +7 more	View in SCUBA
Glial cells	Glial Myelination Identity Myelination	AP1S2, CALM2, CD81, CD9, COMT, GPM6B, GSN, LGALS1 +6 more	View in SCUBA
Innate lymphoid cells	ILC3 identity Differentiation	BHLHE40, BRD4, CASK, CITED2, GLUL, GNAS, HECA, IQGAP1 +19 more	View in SCUBA
Monocytes	Inflammatory Monocyte Activation Inflammatory	ANG, ANXA2, CD99, MGST1, PLAAT3, RNASE2, S100A10, ST14	View in SCUBA
Mucosal-associated invariant T cell	NK-like Cytotoxic cytotoxicity	AKR1C3, BNC2, CLIC3, CX3CR1, FCGR3A, FGFBP2, GNLY, KIR3DL1 +3 more
Natural Killer cells	NK Homing Adhesion Homing & TEM	CHST2, ITGAM, LAIR1, MLC1, MYOM2, NCR3, SPN	View in SCUBA
Pericytes	Complement Regulatory Pericyte Inflammatory	ACTN1, CD63, CFH, LGALS1, MGP, SELENOM, SERPING1	View in SCUBA
Smooth muscle cells	Pericyte Notch Identity Development	CD59, EIF1, GPNMB, HEYL, IFITM2, INAFM1, ITM2B, PDGFRB +2 more	View in SCUBA

About the gene

Synonyms	FSTL2, IGFBP-7, MAC25, PSF
Chromosome	4: 57030773-57110385
Predicted location	Secreted
Essential gene	No
Protein class	Disease related genes, Plasma proteins, Predicted secreted proteins
Molecular function	Growth factor binding
Biological process	Cell adhesion

Function

Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.