CD59 — CD59 molecule (CD59 blood group)
CD59 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD59's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell exhaustion Exhaustion | CD247, CD38, FLT1, GAN, IKBKB, LAG3, LRBA, PTMS +3 more | View in SCUBA |
| Endothelial | Oxidative Stress Response Stress | AHR, CD151, CTTNBP2NL, DSTN, FLOT2, GNB4, GNG5, HYAL2 +11 more | View in SCUBA |
| Gamma-delta T cells | IRF4 T-cell Activation T cell maturation | APOA1, APOA4, FCER1G, FES, FUCA1, GEM, GRAMD2B, HMOX1 +14 more | |
| Glial cells | Oxidative Stress Response Stress | CAP1, CXXC5, EEF2, ENO1, HNRNPF, KLF9, NDUFA11, NFE2L2 +3 more | View in SCUBA |
| Lymphatic endothelial | Oxidative Stress Response Stress | ANXA5, ATP6V0B, CCT3, DRAP1, EIF5A, GPX4, NUPR1, PDLIM4 +3 more | View in SCUBA |
| Monocytes | Monocyte Tissue Infiltration Migration & adhesion | CDCP1, FPR3, NRP1, NRP2, PDE4DIP, PLAU, PMP22, PTMS +3 more | View in SCUBA |
| Smooth muscle cells | Pericyte Notch Identity Development | EIF1, GPNMB, HEYL, IFITM2, IGFBP7, INAFM1, ITM2B, PDGFRB +2 more | View in SCUBA |
About the gene
| Synonyms | 16.3A5, EJ16, EJ30, EL32, G344, MIC11, MIN1, MIN2, MIN3, MSK21, p18-20 |
|---|---|
| Chromosome | 11: 33703010-33736479 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
Function
Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit complement membrane attack complex (MAC) assembly on cell membranes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.