HP — Haptoglobin
HP belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | Secondary Granule Antibacterial Degranulation | CAMP, CHI3L1, CHIT1, CRISP3, CYBB, LCN2, LTF, MMP8 +3 more |
About the gene
| Chromosome | 16: 72054505-72061055 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins |
| Molecular function | Antibiotic, Antimicrobial, Antioxidant, Serine protease homolog |
| Biological process | Acute phase, Immunity |
Function
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.