LCN2 — Lipocalin 2
LCN2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LCN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | MHC Class II Antigen Presentation Immune function | C2, CD74, HLA-DMA, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-DRB1 +2 more | View in SCUBA |
| Neutrophils | Secondary Granule Antibacterial Degranulation | CAMP, CHI3L1, CHIT1, CRISP3, CYBB, HP, LTF, MMP8 +3 more |
About the gene
| Synonyms | 24p3, NGAL |
|---|---|
| Chromosome | 9: 128149071-128153453 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins |
| Biological process | Apoptosis, Immunity, Innate immunity, Ion transport, Iron transport, Transport |
Function
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron- free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.