CHIT1 — Chitinase 1
CHIT1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHIT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | SPP1 Tissue Remodeling ECM remodeling | BST1, CD52, CHI3L1, CSF1, FBP1, FGR, FN1, GCHFR +19 more | View in SCUBA |
| Neutrophils | Secondary Granule Antibacterial Degranulation | CAMP, CHI3L1, CRISP3, CYBB, HP, LCN2, LTF, MMP8 +3 more |
About the gene
| Synonyms | CHI3, CHIT |
|---|---|
| Chromosome | 1: 203212827-203273641 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted secreted proteins |
| Molecular function | Glycosidase, Hydrolase |
| Biological process | Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation |
Function
Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.