CHI3L1 — Chitinase 3 like 1
CHI3L1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHI3L1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammatory ECM Remodeling ECM remodeling | ABRACL, ADAMTS2, CD82, COTL1, GGCT, LXN, MT2A, NID2 +5 more | View in SCUBA |
| Macrophages | SPP1 Tissue Remodeling ECM remodeling | BST1, CD52, CHIT1, CSF1, FBP1, FGR, FN1, GCHFR +19 more | View in SCUBA |
| Neutrophils | Secondary Granule Antibacterial Degranulation | CAMP, CHIT1, CRISP3, CYBB, HP, LCN2, LTF, MMP8 +3 more |
About the gene
| Synonyms | GP39, YK-40, YKL40 |
|---|---|
| Chromosome | 1: 203178931-203186704 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Antimicrobial |
| Biological process | Apoptosis, Inflammatory response |
Function
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia- induced injury, inflammation and epithelial apoptosis in lung.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.