Secondary Granule Antibacterial
Gene co-expression module in Neutrophils
| Category | Degranulation |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes are canonical neutrophil secondary and tertiary granule antimicrobial proteins: LTF/lactoferrin (secondary granule, iron chelation/antimicrobial), MMP8/collagenase-2 (tertiary granule, matrix degradation), PGLYRP1 (peptidoglycan recognition, bactericidal), TCN1/transcobalamin-1 (specific granule, vitamin B12 binding/antimicrobial), CRISP3 (specific granule protein), LCN2/lipocalin-2 (secondary granule, iron sequestration/bacteriostatic), CAMP/LL-37 cathelicidin (secondary granule, broad-spectrum antimicrobial), HP/haptoglobin (acute phase), CHIT1 (chitinase, antifungal/antibacterial), CYBB/NOX2 (NADPH oxidase, oxidative burst), CHI3L1 (chitinase-like). This is a definitive neutrophil specific/secondary/tertiary granule degranulation and antibacterial effector module, distinct from M70 which captures primary granule/azurophil defensins.
Genes
CAMP, CHI3L1, CHIT1, CRISP3, CYBB, HP, LCN2, LTF, MMP8, PGLYRP1, TCN1, TFF3
Most correlated modules
- Immature Neutrophil Granule · correlation 0.83
- NET Priming State · correlation 0.65
- Endocytic Vesicular Trafficking · correlation 0.62
- Actin Cytoskeleton Dynamics · correlation 0.57
- Apoptotic Neutrophil Program · correlation 0.56
- mRNA Splicing Processing · correlation 0.55
- Specific Granule Release · correlation 0.52
- Myeloid Lipid Remodeling · correlation 0.42
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.