IL1RL1 — Interleukin 1 receptor like 1
IL1RL1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL1RL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Mast Cell Basophil Granulocyte development | ENPP3, HPGD, ITGB8, KRT1, NDFIP2, SLC18A2, TPSB2, TPSD1 +1 more |
About the gene
| Synonyms | DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1 |
|---|---|
| Chromosome | 2: 102311502-102352037 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Receptor |
Function
Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2- dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3- dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). Inhibits IL-33 signaling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.