Mast Cell Basophil
Gene co-expression module in Hematopoietic progenitor cells
| Category | Granulocyte development |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
This module contains multiple mast cell and basophil markers: TPSD1 and TPSB2 (mast cell tryptases), SLC18A2 (VMAT2, vesicular monoamine transporter expressed in mast cells/basophils for histamine storage), IL1RL1 (ST2/IL-33 receptor, highly expressed on mast cells and basophils), ENPP3 (ecto-5'-nucleotidase-related, basophil/eosinophil marker, also called CD203c on basophils), HPGD (prostaglandin catabolism). The module sits in the neighborhood of M28 and M37 (mast cell modules), confirming a mast cell/basophil identity. Low expression (2.9%) is consistent with a rare progenitor population.
Genes
ENPP3, HPGD, IL1RL1, ITGB8, KRT1, NDFIP2, SLC18A2, TPSB2, TPSD1, VWA5A
Most correlated modules
- Mast Cell Differentiation · correlation 0.92
- Eosinophil Differentiation · correlation 0.87
- Myeloid Lipid Signaling · correlation 0.81
- Mast Cell Progenitor · correlation 0.73
- HPC Stemness Program · correlation 0.64
- ER Protein Folding · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.