NDFIP2 — Nedd4 family interacting protein 2
NDFIP2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NDFIP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ATP5MC1, BATF, CTLA4, DNPH1, GBP2, IL2RA, NAMPT, NINJ2 +6 more | View in SCUBA |
| CD8⁺ T cells | Cytotoxic Exhausted CD8 Exhaustion | CCL3, CD2BP2, CLEC2D, CTSD, DUSP4, GZMB, PHLDA1, PRF1 +2 more | View in SCUBA |
| Gamma-delta T cells | Cholesterol Biosynthesis Housekeeping | CRIM1, CSF1, HS3ST3B1, LDLR, MSMO1, MUC12, REG1A, SQLE +1 more | |
| Hematopoietic progenitor cells | Mast Cell Basophil Granulocyte development | ENPP3, HPGD, IL1RL1, ITGB8, KRT1, SLC18A2, TPSB2, TPSD1 +1 more |
About the gene
| Synonyms | KIAA1165, N4wbp5a |
|---|---|
| Chromosome | 13: 79481155-79556077 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation. May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.