ITGB8 — Integrin subunit beta 8
ITGB8 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITGB8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh CXCL13 program B cell help | ASCL2, C11orf96, CD8B2, CXCL13, CXXC5, FILIP1L, FZD3, GFOD1 +5 more | View in SCUBA |
| Enterocytes | YAP cytoskeletal remodeling Migration & adhesion | ABLIM1, AHCYL2, ARHGAP26, CCSER1, CDC42BPA, FGD4, PDE4D, PIP5K1B +5 more | View in SCUBA |
| Glial cells | TGF-beta ECM Remodeling ECM remodeling | GALNT2, HCFC1R1, LOXL3, PDGFA, RCAN1, S1PR3, SPRY1 | View in SCUBA |
| Hematopoietic progenitor cells | Mast Cell Basophil Granulocyte development | ENPP3, HPGD, IL1RL1, KRT1, NDFIP2, SLC18A2, TPSB2, TPSD1 +1 more | |
| Monocytes | Integrin-mediated Migration Migration & adhesion | DNAAF1, EIF4E, ITGA5, LMNA, MSC, NRIP3, PHLDA1, PNP +7 more | View in SCUBA |
About the gene
| Chromosome | 7: 20330702-20415754 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted membrane proteins |
| Molecular function | Integrin, Receptor |
| Biological process | Cell adhesion |
Function
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.