ITGA8 — Integrin subunit alpha 8
ITGA8 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITGA8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Lamina Propria ECM ECM production | ADAMTS7, ADGRL4, ANGPTL6, BMP2, CBLN2, CYTL1, DHRS7C, FAM135B +14 more | View in SCUBA |
About the gene
| Chromosome | 10: 15513954-15719922 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins |
| Molecular function | Developmental protein, Integrin, Receptor |
| Biological process | Cell adhesion, Differentiation, Neurogenesis |
Function
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.