ITGAD — Integrin subunit alpha D
ITGAD belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITGAD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Effector Cytokine Secretion Inflammation | APBA2, ASPH, CCL3, CCL4, CMC1, CYRIA, DTHD1, DTNBP1 +25 more |
About the gene
| Synonyms | ADB2, CD11d |
|---|---|
| Chromosome | 16: 31393335-31426505 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Molecular function | Integrin, Receptor |
| Biological process | Cell adhesion |
Function
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.