CCL3 — C-C motif chemokine ligand 3
CCL3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADGRG1, ATP8B4, CCL4, CCL4L2, CSF2, FASLG, GNLY, GZMB +10 more | View in SCUBA |
| CD8⁺ T cells | Cytotoxic Exhausted CD8 Exhaustion | CD2BP2, CLEC2D, CTSD, DUSP4, GZMB, NDFIP2, PHLDA1, PRF1 +2 more | View in SCUBA |
| Gamma-delta T cells | Effector Cytokine Secretion Inflammation | APBA2, ASPH, CCL4, CMC1, CYRIA, DTHD1, DTNBP1, FCRL3 +25 more | |
| Monocytes | TNF/IL-1 Cytokine Storm Inflammatory | CCL4, CCL4L2, EGR3, IL1A, IL6, KCNJ2, PTGS2, TNF +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Effector Activation Inflammation | ADGRE5, BCL2A1, CCL20, CCL3L3, CCL4, CCL4L2, DUSP10, EGR2 +10 more | |
| Neutrophils | CC Chemokine Secretion Cytokine & chemokine secretion | C15orf48, CCL20, CCL3L3, CCL4, CCL4L2, CCRL2, CD83, CDKN1A +4 more |
About the gene
| Synonyms | G0S19-1, LD78ALPHA, MIP-1-alpha, SCYA3 |
|---|---|
| Chromosome | 17: 36088256-36090169 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Chemotaxis, Inflammatory response |
Function
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose- dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.