CCL4 — C-C motif chemokine ligand 4
CCL4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCL4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADGRG1, ATP8B4, CCL3, CCL4L2, CSF2, FASLG, GNLY, GZMB +10 more | View in SCUBA |
| CD8⁺ T cells | Cytotoxic Effector cytotoxicity | APOBEC3H, B2M, CCL5, CD52, CYBA, GZMH, HCST, HLA-A +4 more | View in SCUBA |
| Gamma-delta T cells | Effector Cytokine Secretion Inflammation | APBA2, ASPH, CCL3, CMC1, CYRIA, DTHD1, DTNBP1, FCRL3 +25 more | |
| Monocytes | TNF/IL-1 Cytokine Storm Inflammatory | CCL3, CCL4L2, EGR3, IL1A, IL6, KCNJ2, PTGS2, TNF +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Effector Activation Inflammation | ADGRE5, BCL2A1, CCL20, CCL3, CCL3L3, CCL4L2, DUSP10, EGR2 +10 more | |
| Neutrophils | CC Chemokine Secretion Cytokine & chemokine secretion | C15orf48, CCL20, CCL3, CCL3L3, CCL4L2, CCRL2, CD83, CDKN1A +4 more |
About the gene
| Synonyms | Act-2, AT744.1, LAG1, MIP-1-beta, SCYA4 |
|---|---|
| Chromosome | 17: 36103827-36105621 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Chemotaxis, Inflammatory response |
Function
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T- cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1- beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.