CYRIA — CYFIP related Rac1 interactor A
CYRIA belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYRIA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Effector Cytokine Secretion Inflammation | APBA2, ASPH, CCL3, CCL4, CMC1, DTHD1, DTNBP1, FCRL3 +25 more | |
| Macrophages | NF-κB Inflammatory Activation Inflammatory | GPR132, HIVEP1, KMO, NFATC1, NFKB1, PDE4B, PFKFB3, USP36 | View in SCUBA |
| Monocytes | Myeloid Epigenetic Regulation Developmental | GPRC5A, H2AC25, MN1, MTHFD1L, PCGF5, PDE2A, PPP1R14B, RAPH1 +1 more | View in SCUBA |
| Neutrophils | TLR2 Innate Signaling Innate immunity | AATK, CHST15, DHX34, ECE1, ERGIC1, MAP4K4, MKNK1, STK40 +4 more |
About the gene
| Synonyms | CYRI-A, DKFZP566A1524, FAM49A, FLJ11080 |
|---|---|
| Chromosome | 2: 16549459-16666331 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
May negatively regulate RAC1 signaling and RAC1-driven cytoskeletal remodeling (Probable). May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions (Probable)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.