Effector Cytokine Secretion
Gene co-expression module in Gamma-delta T cells
| Category | Inflammation |
|---|---|
| Genes | 34 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 34 genes have a known function matching the annotation |
Why this annotation
Key hub genes CCL3, CCL4, and IFNG define a canonical activated effector cytokine/chemokine secretion program. LYST encodes the lysosomal trafficking regulator essential for cytotoxic granule secretion (mutated in Chediak-Higashi syndrome). VCAM1 and ITGAD reflect activation-induced adhesion molecule upregulation. CYRIA promotes Rac1-mediated actin remodeling for immune synapse formation. NCOA1 and GCSAM may support transcriptional activation. P2RX5 and FCRL3 are expressed on activated lymphocytes. Moderate coherence reflects some peripheral members (HBB likely ambient, PRDM16 outlier), but the core program is a chemokine-producing, IFNG-secreting activated effector state. Embedded in a cytotoxic effector neighborhood alongside KIR+ (M182) and XCL1/XCL2-expressing (M125) modules.
Genes
APBA2, ASPH, CCL3, CCL4, CMC1, CYRIA, DTHD1, DTNBP1, FCRL3, GCSAM, GLIS3, HBB, IFNG, ITGAD, KIF1B, LYST, MAF, NCOA1, P2RX5, PDGFD, PECAM1, PKD1, PLXND1, PRDM16, PTGDR, SH3TC1, TNFRSF9, TNFSF8, TRIO, USP24, VAV3, VCAM1, WASHC1, ZNF296
Most correlated modules
- NK-like Mature gd-T · correlation 0.80
- XCL1/XCL2 Cytotoxic Activation · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.