KCNJ2 — Potassium inwardly rectifying channel subfamily J member 2
KCNJ2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KCNJ2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | TNF/IL-1 Cytokine Storm Inflammatory | CCL3, CCL4, CCL4L2, EGR3, IL1A, IL6, PTGS2, TNF +3 more | View in SCUBA |
About the gene
| Synonyms | IRK1, Kir2.1, LQT7 |
|---|---|
| Chromosome | 17: 70168673-70180044 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Ion channel, Voltage-gated channel |
| Biological process | Ion transport, Potassium transport, Transport |
Function
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.