KCNK17 — Potassium two pore domain channel subfamily K member 17
KCNK17 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KCNK17's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Naive B Cell Lymphcyte development | CCR7, CLNK, DYRK2, EVL, FCMR, HLX, IGHD, IGHM +4 more |
About the gene
| Synonyms | K2p17.1, TALK-2, TALK2, TASK-4, TASK4 |
|---|---|
| Chromosome | 6: 39299001-39314461 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
| Biological process | Ion transport, Potassium transport, Transport |
Function
K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. Present in the cardiac conduction system where it may regulate action potential duration and beating frequency of cardiac myocytes. Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.