Naive B Cell
Gene co-expression module in Hematopoietic progenitor cells
| Category | Lymphcyte development |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include IGHM and IGHD (immunoglobulin heavy chain mu and delta, defining naive B cells), FCMR (Fc receptor for IgM, expressed on B cells), CCR7 (homing receptor for lymph node/recirculating B cells), ITGAL (LFA-1 integrin, lymphocyte adhesion), CLNK (lymphocyte signaling adaptor), HLX (transcription factor in lymphoid development), PALLD (cytoskeletal scaffold in immune cells), EVL (Ena/VASP family, lymphocyte actin dynamics), RAB31 (vesicular trafficking in B cells), DYRK2 (kinase in B cell signaling), KCNK17 (K+ channel expressed in lymphocytes), SPECC1 (cytoskeletal). The co-expression of IGHM, IGHD, FCMR, CCR7, and CLNK is a hallmark signature of mature naive B cells. As a topological neighbor of M51 and M59, this module represents a more differentiated stage of B-lineage commitment. Concordant genes: IGHM, IGHD, FCMR, CCR7, ITGAL, CLNK, HLX, EVL, RAB31.
Genes
CCR7, CLNK, DYRK2, EVL, FCMR, HLX, IGHD, IGHM, ITGAL, KCNK17, PALLD, RAB31, SPECC1
Most correlated modules
- Lymphoid Progenitor Commitment · correlation 0.92
- Lymphoid Progenitor TFs · correlation 0.92
- HOX HSC Program · correlation 0.92
- T/NK Cell Identity · correlation 0.89
- Myeloid Commitment · correlation 0.88
- Lymphoid-Primed Progenitor · correlation 0.86
- Regulatory T-cell State · correlation 0.85
- Multipotent Progenitor Identity · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.