HLX — H2.0 like homeobox
HLX belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HLX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous Endothelial Identity Endothelial cell development | ACE, ADARB1, CDC42EP1, CLSTN1, EMCN, FLT1, GALNT18, GPRC5B +11 more | View in SCUBA |
| Hematopoietic progenitor cells | Naive B Cell Lymphcyte development | CCR7, CLNK, DYRK2, EVL, FCMR, IGHD, IGHM, ITGAL +4 more |
About the gene
| Synonyms | HB24, HLX1 |
|---|---|
| Chromosome | 1: 220879431-220885059 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding |
| Biological process | Differentiation, Transcription, Transcription regulation |
Function
Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.