SCUBA

EVL — Enah/Vasp-like

EVL belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EVL's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsB-cell antigen presentation
B cell maturation
APBB1IP, BMP2K, BTN2A2, CIITA, CYTH4, HHEX, MS4A1, SLC35D2 +6 moreView in SCUBA
CD4⁺ T cellsTh17 lineage
Th17 fate
ADA, ARHGEF3, CD226, CD52, DENND3, IDH2, IL17RE, IL23R +13 moreView in SCUBA
CD8⁺ T cellsTCR Complex Signaling
TCR Signaling
ACAP1, ANXA1, CD37, CD3E, CITED2, DUSP1, LAPTM5, LCK +4 moreView in SCUBA
EndothelialIL-13/STAT6 Signaling
Inflammation
ABLIM1, ARL2BP, ASRGL1, ATP8B1, BMP1, BMPR2, CLIP1, CMIP +18 moreView in SCUBA
Gamma-delta T cellsActin-based Motility
Cytoskeletal
APBB1IP, CD58, COMMD7, CORO1B, CTSD, FDFT1, HMOX2, OSTF1 +13 more
Hematopoietic progenitor cellsNaive B Cell
Lymphcyte development
CCR7, CLNK, DYRK2, FCMR, HLX, IGHD, IGHM, ITGAL +4 more
Innate lymphoid cellsILC1 Actin Motility
Cytoskeleton & motility
ACAP1, ARHGDIB, CORO1A, DGCR6L, GPSM3, HEXA, LCK, MFGE8 +14 moreView in SCUBA
MacrophagesMacrophage Identity
Innate immunity
CCDC88B, CSF1R, CYP4V2, CYSLTR1, FAM53B, FOXRED2, GATM, GPR155 +15 moreView in SCUBA
Mucosal-associated invariant T cellMAIT Tissue Residence
Tissue residence
ANAPC16, ARHGDIB, ATP5IF1, CD3E, CD53, CD99, CTSD, CXCR6 +7 more
Natural Killer cellsNK Cytoskeletal Activation
Cytoskeleton & motility
CAPG, CLNK, COTL1, GPR82, ITM2A, PEBP1, PGK1, PLEKHO1 +3 moreView in SCUBA

About the gene

SynonymsRNB6
Chromosome14: 99971449-100144236
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins
Molecular functionActin-binding

Function

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.