CCR7 — C-C motif chemokine receptor 7
CCR7 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCR7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NF-kB activation/survival BCR/AP1/NFKb pathway | ARL4C, BCL2A1, DDX21, GNG2, ICAM1, IRF2BPL, LMNA, NAMPT +9 more | View in SCUBA |
| CD4⁺ T cells | Naive T quiescence T cell development | CD55, CRIP2, CSGALNACT1, ITGA6, KLF2, KLF3, NOSIP, RASA3 +6 more | View in SCUBA |
| CD8⁺ T cells | Naive/Central Memory T cell maturation | AIF1, ATM, FCMR, FOXP1, KLF2, KLF3, LDLRAP1, LEF1 +7 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell T cell maturation | ADK, AIF1, ARHGAP15, ARMH1, BACH2, CNR2, DPYD, FAM117B +7 more | |
| Hematopoietic progenitor cells | Naive B Cell Lymphcyte development | CLNK, DYRK2, EVL, FCMR, HLX, IGHD, IGHM, ITGAL +4 more | |
| Mucosal-associated invariant T cell | Naive T cell T cell maturation | AK5, ARID5B, BACH2, CSGALNACT1, FHIT, FOXP1, LEF1, MAL +6 more |
About the gene
| Synonyms | BLR2, CD197, CDw197, CMKBR7, EBI1 |
|---|---|
| Chromosome | 17: 40553769-40565472 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.