FCMR — Fc mu receptor
FCMR belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FCMR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Adhesion/Migration migration & adhesion | ADAM28, ADAMTS6, ARHGAP24, ARHGAP5, CHPT1, CLMN, CMTR2, JAM3 +11 more | View in SCUBA |
| CD4⁺ T cells | TCR signaling activation TCR/AP1/NFKb pathway | CNST, CORO1B, DAPP1, ECI1, FAAH2, GPCPD1, KLHL24, MLLT3 +8 more | View in SCUBA |
| CD8⁺ T cells | Naive/Central Memory T cell maturation | AIF1, ATM, CCR7, FOXP1, KLF2, KLF3, LDLRAP1, LEF1 +7 more | View in SCUBA |
| Gamma-delta T cells | EOMES Effector Program T cell maturation | AGK, ANKZF1, ATG16L2, C6orf120, CARD8, CBX1, CDK5RAP3, CENPT +25 more | |
| Hematopoietic progenitor cells | Naive B Cell Lymphcyte development | CCR7, CLNK, DYRK2, EVL, HLX, IGHD, IGHM, ITGAL +4 more | |
| Mucosal-associated invariant T cell | T cell Homeostasis T cell maturation | APOL6, CD40LG, CNDP2, FAM118A, GPR171, IFIH1, IL7R, ISG20 +19 more | |
| Natural Killer cells | NK Cell Identity Differentiation | APBA2, APMAP, COLQ, ETS1, FKBP11, GSAP, ICAM2, MRPL10 +2 more | View in SCUBA |
About the gene
| Synonyms | FAIM3, FcmuR, TOSO |
|---|---|
| Chromosome | 1: 206903317-206923247 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
| Biological process | Immunity |
Function
High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM. Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane- bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues. Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF- kappa-B, MAP kinases and calcium signaling pathways.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.