KLHL11 — Kelch like family member 11
KLHL11 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KLHL11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Transcription-RNA Coupling DNA/chromatin regulation | AKNA, AP1G1, BTAF1, BZW1, CRNKL1, DDX6, DNTTIP2, DYNC1H1 +26 more |
About the gene
| Synonyms | FLJ10572 |
|---|---|
| Chromosome | 17: 41848518-41865423 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.