Transcription-RNA Coupling
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 35 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 35 genes have a known function matching the annotation |
Why this annotation
EP300 (p300) and SETD2 are major chromatin writers (histone acetyltransferase and H3K36 methyltransferase, respectively). SUPT5H (SPT5) is a transcription elongation factor. SF3A1 is a core spliceosome component. DDX6 and YTHDF3 participate in m6A-dependent RNA metabolism and P-body assembly. EIF4H and EIF4G2 are translation initiation factors. AP1G1 is a clathrin adaptor for vesicle trafficking. DYNC1H1 is dynein heavy chain. The module integrates transcription elongation/chromatin writing with co-transcriptional splicing and m6A RNA metabolism, representing a coupled transcription-RNA processing program. Strong coherence supports a unified program.
Genes
AKNA, AP1G1, BTAF1, BZW1, CRNKL1, DDX6, DNTTIP2, DYNC1H1, EDRF1, EIF4G2, EIF4H, EP300, ISG20L2, KDM2B, KLHL11, LCOR, MADD, PLEKHM1, PRKCH, PRRC2C, RBM33, RIOK3, SAFB2, SCAF8, SDE2, SENP5, SETD2, SF3A1, SRRT, SUPT5H, TFIP11, USP38, YTHDF3, ZNF451, ZZEF1
Most correlated modules
- Hippo Pathway Signaling · correlation 0.94
- Hypoxia Stress Response · correlation 0.92
- Wnt-STAT3 Signaling · correlation 0.89
- mRNA Decay Regulation · correlation 0.89
- MAPK Kinase Signaling · correlation 0.83
- T cell Identity Signaling · correlation 0.81
- Histone Demethylase Program · correlation 0.79
- Chromatin Epigenetic Regulation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.