BZW1 — Basic leucine zipper and W2 domains 1

BZW1 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

BZW1's module in each cell type

Cell type	Module	Shares the module with
CD8⁺ T cells	Proteostasis Translation Protein processing & ER	CCT5, CCT7, EIF2S2, HNRNPC, HNRNPM, MDH1, PCBP1, PSMD13 +3 more	View in SCUBA
Fibroblasts	ER Stress UPR Stress	ARF4, B4GALT1, BTG3, CYCS, EFHD2, ELOC, LDHA, LITAF +6 more	View in SCUBA
Gamma-delta T cells	Transcription-RNA Coupling DNA/chromatin regulation	AKNA, AP1G1, BTAF1, CRNKL1, DDX6, DNTTIP2, DYNC1H1, EDRF1 +26 more
Goblet cells	Ubiquitin Protein Homeostasis Housekeeping	ARPC2, CMTM6, CSNK1A1, DAP, EMP2, GNAI3, KIF5B, MORF4L1 +6 more	View in SCUBA
Innate lymphoid cells	RNA Processing & Proteostasis RNA processing & translation	CBX5, CSNK1A1, DDX21, EIF2S1, EIF3J, ENPP1, FNBP1, HNRNPA3 +11 more	View in SCUBA
Lymphatic endothelial	mRNA Translation Regulation RNA processing & translation	BTF3, CLIC1, EEF1B2, GAPDH, NPM1, SDCBP, YBX1, YWHAE	View in SCUBA
Macrophages	Osmotic Stress Response Stress	ANKRD28, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3, FURIN +25 more	View in SCUBA
Monocytes	Wnt/AP-1 Activation Inflammatory	B4GALT1, CHD1, CTNNB1, ETF1, FOSL2, GABARAPL1, GPCPD1, PNPLA8 +2 more	View in SCUBA
Mucosal-associated invariant T cell	Stress Granule Response Stress	CRTC2, EZR, G3BP2, HERPUD2, HNRNPUL1, MAP3K8, MAPK1IP1L, RNF138 +3 more
Natural Killer cells	TGF-beta Repression DNA regulation & transcription	GTF2B, HBP1, ODC1, POLR2K, SKIL, SKP1, SPTY2D1, UBE2D3	View in SCUBA
Smooth muscle cells	ER-Golgi Secretory Pathway Protein processing & ER	CCT3, COL15A1, GPC6, IFT57, KDELR2, LRPAP1, NFATC4, PAM +4 more	View in SCUBA

About the gene

Synonyms	5MP2, BZAP45, KIAA0005
Chromosome	2: 200810594-200827338
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	Activator
Biological process	Transcription, Transcription regulation, Translation regulation

Function

Translation initiation regulator which represses repeat- associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function. Enhances histone H4 gene transcription but does not seem to bind DNA directly.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.