LEMD3 — LEM domain containing 3
LEMD3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LEMD3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Mucosal-associated invariant T cell | Rho GTPase Migration migration & adhesion | GNA13, HAPSTR1, HIPK1, LUZP1, MYO9B, PPP1CB, PPP1R16B, PPP4R3A +4 more |
About the gene
| Synonyms | MAN1 |
|---|---|
| Chromosome | 12: 65169583-65248355 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins |
| Molecular function | DNA-binding |
Function
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.