Rho GTPase Migration
Gene co-expression module in Mucosal-associated invariant T cell
| Category | migration & adhesion |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
This module's hub genes include GNA13 (heterotrimeric G-protein alpha-13 subunit, involved in cytoskeletal remodeling and cell motility), PPP1CB and PPP4R3A (serine/threonine phosphatases regulating cytoskeletal dynamics), PTPN1 (PTP1B, tyrosine phosphatase), PREX1 (Rac1 GEF activated by G-beta-gamma and PI3K, key regulator of cell migration), MYO9B (myosin IXb, a Rho GAP-containing motor protein involved in immune cell migration), LUZP1 (cytoskeletal organizer), and LEMD3 (inner nuclear membrane protein). PPP1R16B regulates myosin phosphatase. QKI is an RNA-binding protein implicated in cell differentiation. HAPSTR1 and HIPK1 are stress/signaling kinases. The module strongly converges on Rho/G-protein signaling regulating cytoskeletal dynamics and cell migration, which is consistent with MAIT cell tissue surveillance and migration programs. Neighbor modules (M117, M131) are chromatin/regulatory, suggesting this neighborhood reflects broad homeostatic programs rather than activated states.
Genes
GNA13, HAPSTR1, HIPK1, LEMD3, LUZP1, MYO9B, PPP1CB, PPP1R16B, PPP4R3A, PREX1, PTPN1, QKI, SEC14L1
Most correlated modules
- RUNX3 Tissue Identity · correlation 0.91
- NF-κB Survival Signaling · correlation 0.88
- NF-κB Activation · correlation 0.85
- NF-κB RNA Regulation · correlation 0.84
- Splicing Regulation · correlation 0.83
- Tissue Residency · correlation 0.83
- Tissue Residency Regulation · correlation 0.83
- Metabolic Homeostasis · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.