PPP1R16B — Protein phosphatase 1 regulatory subunit 16B
PPP1R16B belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPP1R16B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Integrin Rap1 Signaling migration & adhesion | ARL3, ATP2B4, ATXN1, DR1, GDE1, GNA15, GRAMD1B, GTDC1 +8 more | View in SCUBA |
| Gamma-delta T cells | cAMP Lipid Signaling Immune regulation | ABL1, AKIRIN2, B9D2, CEMIP2, CHPT1, CTDP1, DKK3, GGA2 +15 more | |
| Lymphatic endothelial | Lipid Metabolic Regulation Lipid metabolism | ANKS1A, CSGALNACT1, DYSF, EFNA5, KALRN, LDB2, MLLT10, PLD1 +5 more | View in SCUBA |
| Mucosal-associated invariant T cell | Rho GTPase Migration migration & adhesion | GNA13, HAPSTR1, HIPK1, LEMD3, LUZP1, MYO9B, PPP1CB, PPP4R3A +4 more | |
| Natural Killer cells | NK/ILC Differentiation Differentiation | ARHGAP9, CHKA, CHPT1, PIM2, PITPNC1, STAM, ZBTB16 | View in SCUBA |
| Pericytes | Pericyte Contractile Tone Cytoskeletal | CARD10, CARD8, EHD4, FAM110D, IL27RA, KANK3, LDB2, NOSTRIN +4 more | View in SCUBA |
About the gene
| Synonyms | ANKRD4, KIAA0823, TIMAP |
|---|---|
| Chromosome | 20: 38805697-38923024 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation. Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the dephosphorylation of EEF1A1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.