LUZP1 — Leucine zipper protein 1
LUZP1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LUZP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TNF/NF-kB activation TCR/AP1/NFKb pathway | BIRC3, DUSP10, GABARAPL1, HNRNPC, MDFIC, NSUN6, PMAIP1, RBBP8 +6 more | View in SCUBA |
| Endothelial | Endocytic Membrane Remodeling migration & adhesion | ARHGAP23, BNIP2, CDK17, EIF4G2, HERC1, KCTD15, LPCAT1, LRRC8A +4 more | View in SCUBA |
| Enterocytes | Colonocyte differentiation signaling Epithelial development | APPL2, BTBD9, BTNL8, CA13, CRACD, DENND5B, NEDD4, RALGPS1 +2 more | View in SCUBA |
| Innate lymphoid cells | Cell Cycle Entry Cell cycle | CCND2, EIF1B, ENY2, KMT2E, RAB8A, TPM4 | View in SCUBA |
| Mucosal-associated invariant T cell | Rho GTPase Migration migration & adhesion | GNA13, HAPSTR1, HIPK1, LEMD3, MYO9B, PPP1CB, PPP1R16B, PPP4R3A +4 more |
About the gene
| Synonyms | LUZP |
|---|---|
| Chromosome | 1: 23084030-23177808 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
F-actin cross-linking protein. Stabilizes actin and acts as a negative regulator of primary cilium formation. Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers. Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis. Binds to microtubules and promotes epithelial cell apical constriction by up- regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.