PPP1CB — Protein phosphatase 1 catalytic subunit beta

PPP1CB belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PPP1CB's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	TCR signaling TCR/AP1/NFKb pathway	AP3M2, ATP1B3, CREM, CRYBG1, DCTN6, EZR, FAM177A1, FTH1 +19 more	View in SCUBA
Endothelial	IL-13/STAT6 Signaling Inflammation	ABLIM1, ARL2BP, ASRGL1, ATP8B1, BMP1, BMPR2, CLIP1, CMIP +18 more	View in SCUBA
Fibroblasts	Rho-ROCK Contractility Cytoskeletal	ANXA6, ATP2B4, CBX6, CSDE1, DYNLT3, GNG12, ITM2C, ROCK1 +1 more	View in SCUBA
Gamma-delta T cells	Chromatin Epigenetic Regulation DNA/chromatin regulation	ADNP2, ARID4B, CEBPZ, ELL2, ENSG00000285976, ETF1, HIPK1, JMJD1C +17 more
Innate lymphoid cells	ER-Golgi Trafficking Protein processing & ER	ATP2B1, ATP6V1D, CAPZA2, CGGBP1, CNOT4, COPS5, CRIPT, CSTB +15 more	View in SCUBA
Macrophages	ER-Golgi Trafficking Vesicular traficking	ADD1, AFTPH, AZIN1, COPA, DYNC1H1, HNRNPC, JOSD1, LCP2 +23 more	View in SCUBA
Mucosal-associated invariant T cell	Rho GTPase Migration migration & adhesion	GNA13, HAPSTR1, HIPK1, LEMD3, LUZP1, MYO9B, PPP1R16B, PPP4R3A +4 more
Natural Killer cells	NK Cell Activation activation	AKAP9, AKIRIN1, ALG13, DDX24, EIF1AX, ETF1, EZR, GNL3 +2 more	View in SCUBA
Smooth muscle cells	Basal Maintenance Genes Housekeeping	ANAPC16, C1QTNF2, C7orf50, CCNI, COX14, COX8A, HNRNPA1, MRPL33 +3 more	View in SCUBA

About the gene

Synonyms	MP, PP-1B, PP1B, PP1beta, PP1c, PPP1beta
Chromosome	2: 28751640-28802940
Predicted location	Intracellular
Essential gene	Yes
Protein class	Disease related genes, Enzymes, Essential proteins, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Molecular function	Hydrolase, Protein phosphatase
Biological process	Biological rhythms, Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism

Function

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.