GNA13 — G protein subunit alpha 13
GNA13 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNA13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Caveolae Mechanosensing Cytoskeletal | APLP2, ARHGAP18, BDKRB2, CACNA1H, CAV1, CAV2, CD9, CPED1 +10 more | View in SCUBA |
| Gamma-delta T cells | MAPK Kinase Signaling TCR Signaling | ARIH1, B4GALT1, BRAF, CDK16, CHD1, DYRK1A, KDM2A, MAP3K2 +8 more | |
| Macrophages | NF-κB AP-1 Signaling Inflammatory | ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more | View in SCUBA |
| Monocytes | G-protein Membrane Remodeling Migration & adhesion | ADA, ANKRD9, CXCL16, DNMBP, EPB41L3, GFOD1, GNA12, MRAS +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | Rho GTPase Migration migration & adhesion | HAPSTR1, HIPK1, LEMD3, LUZP1, MYO9B, PPP1CB, PPP1R16B, PPP4R3A +4 more | |
| Natural Killer cells | TGF-beta Response Immune regulation | ANKRD9, AUTS2, CDK17, MTFP1, N4BP3, RAB5IF, RBM38, TAMALIN +2 more | View in SCUBA |
About the gene
| Synonyms | G13, MGC46138 |
|---|---|
| Chromosome | 17: 65009289-65056740 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Transducer |
Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in a process independent from Rho activation. In lymphoid follicles, transmits P2RY8- and S1PR2-dependent signals that lead to inhibition of germinal center (GC) B cell growth and migration outside the GC niche.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.