LETM1 — Leucine zipper and EF-hand containing transmembrane protein 1
LETM1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LETM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Glycosylation & trafficking Protein processing & ER | AASDHPPT, ABHD12, ACTR1A, ANKRD35, AP1S1, ARRDC1, ATF6B, ATG5 +25 more | View in SCUBA |
About the gene
| Synonyms | Mdm38, SLC55A1. |
|---|---|
| Chromosome | 4: 1811479-1856156 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Human disease related genes, Predicted membrane proteins, Transporters |
| Biological process | Antiport, Calcium transport, Ion transport, Potassium transport, Transport |
Function
Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion. Also functions as an electroneutral mitochondrial proton/potassium exchanger. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.